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To test that hypothesis, Diamond again turned to work in both humans and animals. Conditions under which young children CAN hold two rules in mind and inhibit a prepotent response. doi:10.1037//0012-1649.38.3.352 PMID:12005379 (abstract) (pdf) Diamond, A. Diamonds team studied children and animal models, combining neurochemical and behavioral work in animals --creating the first animal model of treated PKU along the way -- with longitudinal testing of an extensive battery of neurocognitive tasks in infants and children. Diamonds team had found converging evidence from two very different domains, vision and cognition, in support of her hypothesis about the mechanism causing cognitive deficits in PKU children when their Phe levels were maintained at what had been thought to be safe levels (3-5 times normal; 360-600 μmol/L). PFC cognitive deficits were closely related to childrens levels of Phe. The deficit in contrast sensitivity was closely related to what the childrens Phe levels had been during the first month of life. Sorting between theories of perseveration: Performance in conflict tasks requires memory, attention, and inhibition [Response]. doi:10.1111/1467-7687.00300 (abstract) (pdf) Diamond, A., Lee, E-Y., & Hayden, M. Early success in using the relation between stimulus and reward to deduce an abstract rule: Perceived physical connectedness is key. doi:10.1037/0012-1649.39.5.825 PMID:12952397 (abstract) (pdf) Diamond, A., Kirkham , N.

We hope our research might fundamentally change the approach and underlying assumptions (i.e., shift the paradigm) of how to improve cognitive skills and how to educate children.

One of those relates to attention-deficit hyperactivity disorder (ADHD).

We predict, and are testing, that physicians prescribing the correct dose of psychostimulants for controlling hyperactivity in patients with ADHD are prescribing too high a dose for patients cognitive problems.

She has made discoveries that have improved treatment for two different medical disorders and discoveries that have impacted education, improving the lives of millions of children. EFs include being able to 'think outside the box' and see things from other perspectives (cognitive flexibility), mentally relating different ideas and facts to one another (working memory), and giving a considered response rather than an impulsive one, resisting temptations, and staying focused (inhibitory control, including selective attention). In 2016, she gave 2731 addresses: many were in BC and ON but others were in the US (CA, MA, NC, NY, TX) and abroad (Israel, South Africa).

Her work has shown that executive functions can be improved even in the very young. These abilities are crucial for problem-solving, creativity, and reasoning, and for success in all life's aspects. In 2017, she gave 26 invited addresses, including in Australia, Israel, Italy, Spain, Sweden, New Zealand, and throughout North America.

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